Manchester City currently sits in second place on the table, boasting 17 points from their opening seven games, while United sits in fifth place on the table having lost their first two games but picked maximum points in their last four.
Ahead of the contest on the 2nd of October, below is two ways Erik ten Hag could line up the Reds for battle.
While David De Gea is tipped to remain in post in both lineups, Lisandro Martinez and Tyrell Malacia may drop could for Harry Maguire and Luke Shaw in the second lineup, with Scott McTominay also poised to come in for Fred in defensive midfield.
Marcus Rashford and Antony Santos are expected to start in any formation Erik ten Hag decides to go with, as the attacking giants could cause a problem for City with their pace in the final third.
Cristiano Ronaldo-who netted his first goal against Sheriff Tiraspol in the Europa League is not expected to start in both lineups, as the 37-years old has not been in great form this season.
Christian Eriksen, meanwhile, has been arguably United’s best midfielder this season as the Danish playmaker has helped connect the Red’s defense and attack.
Bruno Fernandes similarly has been in great form this season, and a midfield of him and Christian Eriksen could cause great problems for Pep Guardiola’s side.